Publications
My personal mission is to guide students to reach their full potential and push the boundaries of our knowledge through research. The broad focus of our research is to define the spatiotemporal regulation of inflammation and how it controls vascular disease.
Find all our Publications on PUBMED: https://www.ncbi.nlm.nih.gov/myncbi/1juk4niEZdk5w/bibliography/public/
Burton JC, Antoniades W, Okalova J, Roos MM, Grimsey NJ. Atypical p38 Signaling, Activation, and Implications for Disease. Int J Mol Sci. 2021 Apr 17;22(8). doi: 10.3390/ijms22084183. Review. PubMed PMID: 33920735; PubMed Central PMCID: PMC8073329.
Burton JC, Okalova J, Grimsey NJ. Sci Rep. 2023 May 8;13(1):7477. doi: 10.1038/s41598-023-33953-y. PubMed PMID: 37156828; PubMed Central PMCID: PMC10167256.
Ubiquitination as a Key Regulator of Endosomal Signaling by GPCRs.
Burton JC, Grimsey NJ. Front Cell Dev Biol. 2019;7:43. doi: 10.3389/fcell.2019.00043. eCollection 2019. Review. PubMed PMID: 30984758; PubMed Central PMCID: PMC6449645.
A Tyrosine Switch on NEDD4-2 E3 Ligase Transmits GPCR Inflammatory Signaling.
Grimsey NJ, Narala R, Rada CC, Mehta S, Stephens BS, Kufareva I, Lapek J, Gonzalez DJ, Handel TM, Zhang J, Trejo J. Cell Rep. 2018 Sep 18;24(12):3312-3323.e5. doi: 10.1016/j.celrep.2018.08.061. PubMed PMID: 30232011; PubMed Central PMCID: PMC6226018.
Two NOTCH1 O-fucose sites have opposing functions in mouse retinal angiogenesis.
LoPilato RK, Kroeger H, Mohan SK, Lauderdale JD, Grimsey N, Haltiwanger RS. Glycobiology. 2023 Oct 6;33(8):661-672. doi: 10.1093/glycob/cwad048. PubMed PMID: 37329502; PubMed Central PMCID: PMC10560083.
Fluorescence resonance energy transfer (FRET) spatiotemporal mapping of atypical P38 reveals an endosomal and cytosolic spatial bias.
Burton JC, Okalova J, Grimsey NJ. Sci Rep. 2023 May 8;13(1):7477. doi: 10.1038/s41598-023-33953-y. PubMed PMID: 37156828; PubMed Central PMCID: PMC10167256.
Thiamine insufficiency induces Hypoxia Inducible Factor-1α as an upstream mediator for neurotoxicity and AD-like pathology.
Valle ML, Anderson YT, Grimsey N, Zastre J. Mol Cell Neurosci. 2022 Dec;123:103785. doi: 10.1016/j.mcn.2022.103785. Epub 2022 Oct 12. PubMed PMID: 36241022.
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Phosphoproteomic analysis of thrombin- and p38 MAPK-regulated signaling networks in endothelial cells.
Molinar-Inglis O, Wozniak JM, Grimsey NJ, Orduña-Castillo LB, Cheng N, Lin Y, Gonzalez Ramirez ML, Birch CA, Lapek JD, Gonzalez DJ, Trejo J. J Biol Chem. 2022 Apr;298(4):101801. doi: 10.1016/j.jbc.2022.101801. Epub 2022 Mar 4. PubMed PMID: 35257745; PubMed Central PMCID: PMC8987612.
The Structure and Immune Regulatory Implications of the Ubiquitin-Like Tandem Domain Within an Avian 2'-5' Oligoadenylate Synthetase-Like Protein.
Shepard JD, Freitas BT, Rodriguez SE, Scholte FEM, Baker K, Hutchison MR, Longo JE, Miller HC, O'Boyle BM, Tandon A, Zhao P, Grimsey NJ, Wells L, Bergeron É, Pegan SD. Front Immunol. 2021;12:794664. doi: 10.3389/fimmu.2021.794664. eCollection 2021. PubMed PMID: 35058932; PubMed Central PMCID: PMC8764230.
aPC/PAR1 confers endothelial anti-apoptotic activity via a discrete, β-arrestin-2-mediated SphK1-S1PR1-Akt signaling axis.
Molinar-Inglis O, Birch CA, Nicholas D, Orduña-Castillo L, Cisneros-Aguirre M, Patwardhan A, Chen B, Grimsey NJ, Coronel LJ, Lin H, Gomez Menzies PK, Lawson MA, Patel HH, Trejo J. Proc Natl Acad Sci U S A. 2021 Dec 7;118(49). doi: 10.1073/pnas.2106623118. PubMed PMID: 34873055; PubMed Central PMCID: PMC8670512.
ATF6 is essential for human cone photoreceptor development.
Kroeger H, Grandjean JMD, Chiang WJ, Bindels DD, Mastey R, Okalova J, Nguyen A, Powers ET, Kelly JW, Grimsey NJ, Michaelides M, Carroll J, Wiseman RL, Lin JH. Proc Natl Acad Sci U S A. 2021 Sep 28;118(39). doi: 10.1073/pnas.2103196118. PubMed PMID: 34561305; PubMed Central PMCID: PMC8488632.
Heat shock protein 27 activity is linked to endothelial barrier recovery after proinflammatory GPCR-induced disruption.
Rada CC, Mejia-Pena H, Grimsey NJ, Canto Cordova I, Olson J, Wozniak JM, Gonzalez DJ, Nizet V, Trejo J. Sci Signal. 2021 Aug 31;14(698):eabc1044. doi: 10.1126/scisignal.abc1044. Epub 2021 Aug 31. PubMed PMID: 34516752; PubMed Central PMCID: PMC8538426.
Atypical p38 Signaling, Activation, and Implications for Disease.
Burton JC, Antoniades W, Okalova J, Roos MM, Grimsey NJ*. Int. J. Mol. Sci. 2021, 22, 4183. https://doi.org/10.3390/ijms22084183
Lin Y§, Wozniak JM§, Grimsey NJ§, Girada S, Patwardhan A, Molinar-Inglis O, Smith TH, Gonzalez DJ, Trejo J (2020)
Phospho-proteomic analysis of protease-activated receptor-1 biased signaling reveals novel modulators of endothelial barrier function. PNAS. 117 (9) 5039 5048; DOI: 10.1073/pnas. 1917295117
Burton JC, Grimsey NJ* (2019)
Ubiquitination As A Key Regulator Of Endosomal Signaling by GPCRs. Front Cell Dev Biol. 7:43. doi: 10.3389/fcell.2019.00043. eCollection 2019. Review. PubMed PMID: 30984758; PubMed Central PMCID: PMC6449645.
Grimsey NJ, Lin Y, Narala R, Rada CC, Mejia-Pena H, Trejo J (2019)
G protein Coupled receptors activate p38 MAPK via a non-canonical TAB1-TAB2 and TAB1-TAB3-dependent pathway in endothelial cells. J Biol. Chem. 294(15):5867-5878
Grimsey NJ, Narala R, Rada C, Lapek JD, Metha S, Stephens B, Zhang J, Handel TM, Gonzales DJ and Trejo J (2018)
A Tyrosine Kinase Regulates NEDD4-2 Activation and GPCR Dependent p38 MAP Kinase Signaling. Cell Reports. 24(12):3312-3323.e5. NIHMSID: NIHMS15085211.
Kroeger H, Grimsey NJ, Paxman R, Plate L, Shoulders M, Jones Y, Farquhar M, Tsang SH, Powers E, Wiseman LR, and Lin JH. (2017)
Small Molecule ATF6 Activators Promote Mesendodermal Differentiation. Sci. Signal. 11(517). NIHMSID: NIHMS965841
Dores MR, Grimsey NJ, Mendez F and Trejo J (2016)
ALIX Regulates the Ubiquitin-Independent Lysosomal Sorting of the P2Y1 Purinergic Receptor via a YPXL Motif. PLoS One. Jun 14;11(6):e0157587
Grimsey NJ and Trejo J (2016)
Integration of Endothelial Protease-Activated Receptor-1 Inflammatory Signalling by Ubiquitin. Curr. Opin. Hematol. May;23(3):274-9
Grimsey NJ, Coronel LJ, Cordova IC, and Trejo J (2016)
Recycling and Endosomal Sorting of Protease-Activated Receptor-1 Is Distinctly Regulated by Rab11A and Rab11B Proteins. J. Biol Chem. Jan 29;291(5):2223-36. doi:10.1074/jbc.M115.702993
Dores MR, Lin H, Grimsey NJ, Mendez F and Trejo J (2015)
The a-Arrestin ARRDC3 Mediates ALIX Ubiquitination and G Protein-Coupled Receptor Lysosomal Sorting. Mol. Biol. Cell. Dec 15;26(25):4660-73. doi: 10.1091/mbc.E15-05-0284.
Grimsey NJ, Aguilar, B, Smith TH, Le P, Soohoo AL, Puthenveedu MA, Nizet V and Trejo J (2015)
Ubiquitin Plays an Atypical Role in GPCR-Induced p38 MAP Kinase Activation on Endosomes. J. Cell Biol. 10.1083/jcb.201504007
Kawamura T, Stephens B, Qin L, Yin X, Dores MR, Smith TH, Grimsey NJ, Abagyan R, Trejo J, Kufareva I, Fuster MM, Salanga CL, Handel TM (2014)
A General Method for Site Specific Fluorescent Labeling of Recombinant Chemokines. PLoS One. Jan 28;9(1):e81454.
Grimsey NJ, Lin H, Trejo J (2014)
Endosomal Signaling by Protease-Activated Receptors. Methods Enzymol.;535:389-401. doi: 10.1016/B978-0-12-397925-4.00022-5.
Sembongi H, Miranda M, Han GS, Fakas S, Grimsey NJ, Vendrell J, Carman GM, Siniossoglou S (2013)
Distinct Roles of the Phosphatidate Phosphatases Lipin 1 and 2 During Adipogenesis and Lipid Droplet Biogenesis in 3T3-L1 cells. J. Biol. Chem. Nov 29;288(48):34502-13.
Chen B, Dores MR, Grimsey NJ, Canto I, Barker BL, Trejo J (2011)
Adaptor Protein Complex-2 (AP-2) and Epsin-1 Mediate Protease-Activated Receptor-1 Internalization Via Phosphorylation- and Ubiquitination-Dependent Sorting Signals. J. Biol. Chem. Nov 25;286(47):40760-70
Renna M, Schaffner C, Brown K, Shang S, Tamayo MH, Hegyi K, Grimsey NJ, Cusens D, Coulter S, Cooper J, Bowden AR, Newton SM, Kampmann B, Helm J, Jones A, Haworth CS, Basaraba RJ, DeGroote MA, Ordway DJ, Rubinsztein DC, and Floto, RA (2011)
Azithromycin Blocks Autophagy and May Predispose Cystic Fibrosis Patients to Mycobacterial Infection. J. Clin. Invest. Sep 1;121(9):3554-63
Grimsey NJ, Soto AG, and Trejo J (2011)
Regulation of Protease-Activated Receptor Signaling by Post-Translational Modifications. IUBMB Life. Jun;63(6):403-11
Grimsey NJ, Han GS, O’Hara L, Rochford JJ, Carman CM, and Siniossoglou S (2008)
Temporal and Spatial Regulation of the Phosphatidate Phosphatases Lipin 1 and 2. J. Biol. Chem, 283, 29166-74.
Fawcett KA, Grimsey NJ, Loos RJ, Wheeler E, Daly A, Soos M, Semple R, Syddall H, Cooper C, Siniossoglou S, O'Rahilly S, Wareham NJ, Barroso I. and Rochford JJ (2008)
Evaluating the Role of LPIN1 Variation in Insulin Resistance, Body Weight, and Human Lipodystrophy in U.K. Populations. Diabetes, 57, 2527-33.
Payne VA, Grimsey NJ, Tuthill A, Virtue S, Gray S. Dalla Nora E, Semple R. K, O'Rahilly S, and Rochford JJ (2008)
The Human Lipodystrophy Gene BSCL2/Seipin May Be Essential for Normal Adipocyte Differentiation. Diabetes, 57, 2055-60.
Frigerio G, Grimsey NJ, Dale M, Majoul I and Duden R (2007)
Two Human ARFGAPs Associated with COP-I-coated Vesicles. Traffic. 8(11), 1644-1655.
O’Hara L, Han GS, Peak-hew S, Grimsey NJ, Carman GM, and Siniossoglou S (2006)
Control of Phospholipid Synthesis by Phosphorylation of the Yeast Lipin Pah1p/Smp2p Mg2+-Dependent Phosphatidate Phosphatase. J. Biol. Chem. 281:45, 34537-34548.
Santos-Rosa H, Leung J, Grimsey NJ, Peak-Chew S, and Siniossoglou S (2005)
The Yeast Lipin Smp2 Couples Phospholipid Biosynthesis to Nuclear Membrane Growth. EMBO J. 1;24(11):1931-1941.